antibiotic resistance

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Case Study: Genomic Approaches to Complex Antibiotic-Resistant Infections

Ela Sauerborn from the Helmholtz Al Institute in Munich, Germany, presented at the Nanopore Community Meeting on the “Detection of hidden antibiotic resistance through real-time genomics.” They spoke about a specific case they published on complex pneumonia. Real-time genomics in the clinical microbiology lab is of interest. Sauerborn talked about the increase in carbapenem-resistant Enterobacteriales. […]
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Databases and Sequencing to Reveal the Microbiome of Wastewater Treatment Plants

Tong Zhang from The University of Hong Kong presented at London Calling 2019 on “Mobile antibiotic resistome in wastewater treatment plants revealed by nanopore metagenomic sequencing.” Zhang explained that the work was mainly performed by a student in their research group. The impact of environmental resistance was emphasized with the prevalence of antibiotic resistance genes […]
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Improving the Rediscovery of Biosynthetic Gene Clusters

Allison Guitor spoke at the Nanopore Community Meeting 2019 on “Harnessing long-read sequencing for antibiotic discovery.” Guitor is from McMaster University in Canada. They noted that antibiotic resistance is on the rise, and there are multidrug-resistant infections. One of the challenges is that bacteria have membranes and mechanisms to remove antibiotics. Guitor shared a timeline […]
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Mock Community and BAMBI Studies

Matthew Clark from The Genome Analysis Center presented at the Nanopore Community Meeting 2016 a session with the title “MinION metagenomics: from mock communities to clinical samples.” They took a mock community with twenty equimolar genomes. They were impressed with the results: 98%+ aligned, and there were long alignments. At the time, the group used […]
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Nanopore Sequencing and Bacterial Disease Public Health Testing

Kimberlee Musser from the Wadsworth Center at the New York State Department of Health presented an update at the Nanopore Community Meeting Houston 2023. Wadsworth Center is the largest state public health laboratory with 750 staff! The Wadsworth Center receives CDC and NIH funding and develops new assays. Musser explained that they have their in-house […]
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Point-of-care Metagenomics with ONT

Tonight I watched Madjid Morsli from the Mediterranean Infection Foundation and & Aix-Marselle University in France present at London Calling 2022 on “Point-of-care, real-time, metagenomics-based pathogen genome detection of life-threatening community-acquired meningitis.” They spoke about infectious bacterial meningitis and how the genotype of the pathogen affects prognosis. Morsli noted that at least 200 pathogens have […]
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