Month: May 2024

CoRAL ecDNA Analysis Toolkit

Tonight, I watched the London Calling 2024 session “CoRAL accurately resolves extrachromosomal DNA structures with long-read sequencing.” Matthew Jones from Stanford University was the presenter and spoke about their toolkit to study extrachromosomal (ecDNA) oncogene (focal) amplifications. ecDNA seems to be large (100 kb-50 Mb) circular and highly rearranged. Jones noted it is also rapidly […]
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Adeno-associated Virus Hepatitis

Oscar Enrique Torres Montaguth from the University College London in the UK presented at London Calling 2024 on “Genomic studies of adeno-associated virus hepatitis.” The team identified AAV2 in liver/blood samples of a pediatric hepatitis outbreak in 2022. These AAVs are commonly used as vectors in gene therapy, and hepatitis can occur with treatments. The […]
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From Plant to Publication in a Couse

I have been curious about the title of a session from London Calling 2024: “Empowering scientists with data literacy skills in long-read genomic sequencing.” Katharina Wolff from TU Braunschweig in Germany was the presenter and explained the wide variety of plants and potential for genome sequencing. Wolf and the team wanted to enable students to […]
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Container Labs and Rich Biodiversity

Mrinalini Watsa from the San Diego Zoo Wildlife Alliance presented at London Calling 2024 a session titled “Into the unknown: portable sequencing empowers global conservation genomics.” I believe Watsa presented at a previous London Calling. They spoke about biodiversity loss and how we likely don’t know the true diversity. Watsa presented examples of amphibian genomic […]
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Chromosome End Telomere Length Conservation and Variability

Continuing with the London Calling 2024 sessions available on demand, tonight I watched Carol Greider from the University of California, Santa Cruz, present on “Nanopore sequencing reveals conservation of chromosome end-specific telomere lengths.” Greider spoke about telomeres, DNA sequences at the ends of chromosomes and their roles. Human telomeres consist of tandem repeats of a […]
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Portable Lab for Wastewater DNA Extraction

Tonight, I started watching sessions from London Calling 2024! Rea Kobialka from the Institute of Animal Hygiene and Veterinary Public Health in Germany presented a session entitled “Mobile lab for rapid detection of pathogens in wastewater in sub-Saharan Africa.” They emphasized the importance of surveillance. The research team developed a portable suitcase mobile lab. The […]
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Whole Genome Plasmid Sequencing

Tonight, I watched a recent Oxford Nanopore Technologies video about plasmid sequencing. The title is “A new and improved ‘gold standard’ for complete plasmid verification.” This session was a Knowledge Exchange with Aaron Pomerantz, Segment Marketing Manager at ONT. They spoke about plasmids and their use in molecular biology and industrial processes. Sanger sequencing has […]
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Databases and Sequencing to Reveal the Microbiome of Wastewater Treatment Plants

Tong Zhang from The University of Hong Kong presented at London Calling 2019 on “Mobile antibiotic resistome in wastewater treatment plants revealed by nanopore metagenomic sequencing.” Zhang explained that the work was mainly performed by a student in their research group. The impact of environmental resistance was emphasized with the prevalence of antibiotic resistance genes […]
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Blood Cancer Detection

Tonight, I watched the London Calling 2019 session by Anna Schuh from the University of Oxford in the UK. The title of the presentation was “Global applications of nanopore sequencing in clinical haematology.” Schuh explained that blood cancers are challenging to treat and that patients would benefit from precision medicines. Chronic myeloid leukemia was the […]
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