Month: July 2025

Understanding Alternative Splicing with Blessy R Package

Nadia Davidson from The Walter and Eliza Hall Institute in Australia presented at London Calling 2025. The intriguing title of the session was “Blessy: enabling differential analysis of phased protein domains.” Blessy is a new tool from Davidson’s research group. Davidson spoke about the impact of alternative splicing on protein function. Davidson and team used […]
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Advancements in Antisense Oligonucleotide Design

Joy Goffena from the University of Washington presented at London Calling 2025. The title of the session was “Variant phasing for antisense oligonucleotide design using adaptive sampling.” Goffena explained antisense oligonucleotide (ASO) technology as short DNA or RNA that can bind target RNA to block translation or even modulate splicing. The goal of their work […]
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Ultra-Fast Classifiers for Pediatric Tumors: Insights from Lennart Kester

I am back from SABER and getting settled. Tonight I watched Lennart Kester from the Princess Maxima Center in The Netherlands present on “Ultra-fast deep-learned classification algorithms for diagnosing pediatric CNS and solid tumors” at London Calling 2025. Kester explained that over the years they have observed an increase in the number of tumor entities, […]
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Decoding the Epitranscriptome: Innovative Approaches in rRNA Modifications

Eva Maria Novoa from the Centre for Genomic Regulation in Spain presented at London Calling 2025 on “Decoding the epitranscriptome at single-molecule resolution: towards clinical applications.” Novoa spoke about ribosomal RNA modifications. They study ribosomal RNA modifications. There are more than 12 modifications in rRNA. The new generation of algorithms allows the detection of more […]
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Efficient Genome Assembly with Hifiasm

Haoyu Cheng from Yale University spoke at London Calling 2025 on “Efficient telomere-to-telomere genome assembly with nanopore reads using hifiasm.”Cheng described the challenges of assembling a diploid human genome. In 2022, the first telomere-to-telomere (T2T) human genome was published. One current strategy is to use long-read data and phasing. There are computational challenges. Hifiasm is […]
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Comparing Illumina and ONT for Genome Analysis

After a good vacation in San Miguel de Allende, Mexico, I am back! Tonight I watched Michael Wiley from the University of Nebraska Medical Center in the USA present at London Calling 2025 on “Automated sample-to-answer workflows for whole genome sequencing to investigate hospital-acquired infections.” The public health labs are embedded in the medical center […]
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