Carlos C. Goller

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Centromere Evolution in Gibbons

Gabrielle Hartley from the University of Connecticut presented at London Calling 2023 a session entitled “Telomere-to-telomere nanopore-based genome assembly reveals genomic and epigenetic features of karyotype radiation.” Hartley is a Ph.D. candidate. They are using Nanopore-based sequencing to learn about chromosome evolution in primates. Hartley is focusing on gibbons, small endangered apes with 18-20 species […]
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Characterization of Small eccDNA Involved in Cancer

Fei Xiao from the Beijing Hospital in China presented at London Calling 2023 a session entitled “Small extrachromosomal circular DNAs as biomarkers for potential pan-cancer diagnosis and prognosis.” They defined extrachromosomal DNA (eccDNA) as “circular DNA molecule that is independent of conventional chromosomes and exists widely in eukaryotes” and can vary in length, though most […]
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Structural Variants in Bovine Populations

Tuan Viet Nguyen, a research scientist from Agriculture Victoria in Australia, presented at London Calling 2023 on “Discovering the missing variation: a long-read sequencing study into the structural variation in two dairy breeds.” They defined structural variants (SVs) as larger than 50 bps and can be deletions, duplications, and inversions. Structural variants, Nguyen noted, are […]
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Cotton Diversity Analyses with Nanopore Sequencing

Babita Singh from the CSIR National Botanical Research Institute in India presented at London Calling 2023 on “Exploring targeted genetic diversity in the core Indian cotton germplasm using Oxford Nanopore platforms.” Singh is a postdoctoral fellow and spoke about how “cotton fibers are unicellular epidermal trichomes of ovules” and one of the most abundant crops […]
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Improved Pharmacogenomics with Adaptive Sampling

Tonight I watched the London Calling 2023 session entitled “Advancing targeted haplotyping in pharmacogenomics using adaptive sampling.” Koen Deserranno from Ghent University in Belgium spoke about their research. They are a pharmacist by training and are interested in pharmacogenomics (PGx): personalization of drug therapy based on genomic sequences of the individual. Deserranno spoke about how […]
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Highly Individual Multiplexed Disease Detection

Caroline Koch from the Imperial College London in the UK presented at London Calling 2023 about “Novel screening platform for highly multiplexed biomarker analysis.” Koch is a PH.D. student. They spoke about how humans express diseases differently: we have different genes and live different lives. Koch described the need for individual highly multiplexed platform to […]
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Some of the World’s Largest Conservation Efforts

The London Calling 2023 showcase on conservation included a session entitled “A low-cost, rapid approach to generate non-model genomes for biodiversity and conservation genomics.” Matt Miller Is from Reneco Wildlife Conservation in the United Arab Emirates. They work on conservation and captive breeding. Miller noted that “Reference Genomes are Models.” Miller said that “no genome […]
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Dynamic Adaptive Sampling

Tonight I continued watching the London Calling 2023 Showcase Stage recordings for sessions on targeted sequencing. The speaker was Lukas Weilguny a Ph.D. student from the EMBL-EBI in the UK. The title of the session was “Dynamic, adaptive sampling during nanopore sequencing using Bayesian experimental design.” They worked on a model that takes the sequencing […]
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Sequencing and Assembly of an Endangered Tortoise Genome

Tonight I watched the Oxford Nanopore Technologies (ONT) London Calling 2023 Showcase Stage on Conservation. In this session, Luca Pandolfini from the Italian Institute of Technology in Italy presented “From genome assembly to epigenome characterisation: a nanopore journey in the footsteps of an endangered tortoise.” Pyxis arachnoides is a tiny tortoise that is critically endangered […]
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Medical Mysteries and CRISPR-Cas9 Nanopore Diagnostics

Cecilia C.S. Yeung & Olga Sala-Torra from the Fred Hutchinson Cancer Center presented the session “Potential clinical utility of long-read sequencing in myeloid neoplasms.” They are both clinicians and saw the potential of long-read sequencing for detection of myeloid neoplasms. The assay has the potential to rapid detect cytogenetic aberrations. Sala-Torra spoke about how fusions […]
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