adaptive sampling

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Nanopore Sequencing for Precision Prescribing in Transplantation

Karen Sherwood from The University of British Columbia and Vancouver, spoke at London Calling 2025 on “Adaptive sequencing in transplantation: identifying immune-genomic risk profiles.” The Genome Canada Transplant Consortium (GCTC) was established and funded for nanopore sequencing of HLA epitopes. Now that the funding has ended the group has continued the work through another collaboration. […]
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Long-Read Sequencing: Solving Genetic Diagnostics Challenges

Sebastian Lunk from the Victorian Clinical Genetics Services (VCGS) in Australia spoke at London Calling 2025 on “Long-read sequencing and adaptive sampling solve complex diagnostic conundrums.” VCGS is a not-for-profit subsidiary of Murdoch Children’s Hospital with forty years of clinical genetic service delivery and 20,000 diagnostic tests performed annually. With 330 staff, they have the […]
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Transforming Cancer Care with Nanopore Sequencing

I continued watching the “Nanopore Sequencing Ultra Rich Data for Cancer Research” webinar. It featured Sayonika Mohanta, the Market Segment Manager for Methylation with Oxford Nanopore Technologies (ONT). Mathilde Fiser from the Curie Institute presentation had the title “Transforming Cancer Care: Redefining Cancer Characterization and Predisposition Insights through Nanopore Sequencing.” Fiser explained that the identification of germline alterations […]
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MSK-IMPACT: Innovative Approaches in Targeted Cancer Sequencing

Stephanie Chrysanthou from the Memorial Sloan Kettering Cancer Center in the US spoke at the Nanopore Community Meeting about “Detection of germline alterations in homologous recombination repair genes by adaptive sampling.” They mentioned that pathology comes from the Greek word that is the study of suffering! The Memorial Sloan Kettering Integrated Mutation Profiling of Actionable […]
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Real-time Genomic Characterization of Pediatric Acute Leukemia: UNC Research

The second talk in the session I started watching yesterday was by a postdoctoral fellow from UNC. Julie Geyer from the University of North Carolina Chapel Hill School of Medicine described their research. The title of the talk was “Real-time genomic characterization of pediatric acute leukemia using adaptive sampling.” Leukemia is cancer of the blood. […]
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Unveiling the Potential of Long-Read Sequencing in Newborn Screening

Tonight, I watched Cate Paschal from the Seattle Children’s Hospital. They spoke about “Exploration of long-read sequencing in the resolution of newborn screening.” This was a London Calling 2024 session. Paschal spoke about newborn screening as a diagnostic test for rare diseases. Paschal explained that Pompe disease is a glycogen storage disorder with a prevalence […]
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Nanopore Sequencing Library Prep: Techniques and Comparison

Tonight, I watched Jessica Anderson, a Senior Field Applications Scientist with Oxford Nanopore Technologies (ONT), present at London Calling 2024. The session was part of the Masterclass 2024 series. It was titled “How to select the right library prep workflow for your experiment.” This session started with an introduction describing how nanopore sensing works. Anderson explained that during […]
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Improved Plant Genome Assembly with Ultra-Long Nanopore Sequencing

Bosheng Li from the Institute of Advanced Agricultural Sciences of Peking University in China presented at London Calling 2024. The session’s title was “Plant T2T genome assembly using ultra-long and adaptive nanopore sequencing.” They spoke about the importance of ultra-long reads. These reads produce N50 length >100 kb. These are crucial in the assembly of […]
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KeyGene’s Innovative Approach to Banana Pangenome Research

Alexander Wittenberg from KeyGene in the Netherlands spoke at London Calling 2024 about “Unlocking the banana pangenome: harnessing genetic diversity.” They explained that the genetic diversity of bananas is very low because of the passaging of a single clone. Fusarium wilt and black Sigatoka cause disease and elicit the spraying of large amounts of pesticides. […]
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Real-time Genomic Characterization of Pediatric Acute Leukemia with Adaptive Sampling

Julie Geyer from The University of North Carolina at Chapel Hill presented at London Calling 2024 on “Real-time genomic characterization of pediatric acute leukemia using adaptive sampling. They explained that leukemia can be acute myeloid leukemia or acute lymphoblastic leukemia. The presence of immature cells is typically performed with karyotype analysis, fluorescence in-situ hybridization (FISH), […]
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