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aPOG and Long-read Sequencing

Janessa Laskin from Canada’s Michael Smith Genome Sciences Centre at BC Cancer presented at London Calling 2023 on the “Potential use of nanopore sequencing in clinical cancer genomics.” Laskin is a clinician and medical oncologist. They spoke about the uncertainty of what treatments to select for patients and the idea of personalized medicine. Laskin explained […]
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CNV and SV Detection

Luis Paulin from the Baylor College of Medicine presented at London Calling 2023 a short session entitled “The long and short of structural variants using Oxford Nanopore Sequencing.” Paulin described how genomic variation caused structural variants (SV) and copy number variants (CNV). Using long-read technology allows for access to difficult to sequence genomic regions, thus […]
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Single-cell Mutation Profiling and Engineering

“A single-cell approach to cancer mutation discovery and CRISPR phenotypic modeling” was the title of the London Calling 2023 session by Hanlee Ji from Stanford University. Ji spoke about the use of single cell genomics and variant analysis. They spoke about how cancer mutations and clonal variation can be detected. In addition, CRISPR technologies allow […]
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Long-read Sequencing Lessons from Genomics Thailand

“Filling the gap with long-read sequencing: lessons from Genomics Thailand” is the title of the London Calling session I watched tonight. The speaker was Manop Pithukpakorn from Siriraj Genomics at Mahidol University in Thailand. They spoke about the similarities of the program and Genomics England. The aim of Genomics Thailand is to implement genomics medicine […]
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CyclomicsSeq

jeroen de Ridder from Cyclomics and the University Medical Center Utrecht in the Netherlands presented “CyclomicsSeq: targeted and genome-wide detection of circulating tumor DNA using nanopore consensus sequencing” at London Calling 2022. They spoke about monitoring of treatment response and disease recurrence and avoiding invasive procedures. For this, they focused on cell-free tumor DNA: cfDNA […]
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Early Detection of Changes in Esophageal Adenocarcinomas

Alvin Ng from the Early Cancer Institute at the University of Cambridge in the UK presented at London Calling 2022 on “Early detection of Barrett’s esophagus and esophageal adenocarcinoma using Oxford Nanopore long-read sequencing.” They began by explaining Barrett’s esophagus (BE) as the pre-malignant condition of esophageal adenocarcinoma (EAC) and has three stages: non-dysplastic, low-grade […]
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Variations in Cancer Susceptibility Identified through Long-read Sequencing

Katherine Dixon from The University of British Columbia in Canada spoke at the Nanopore Community Meeting 2022 about “Clinical and functional significance of germline variation in cancer susceptibility and disease.” Dixon spoke about the complexity of factors determining cancer. Between 15-20% of cancer show familial clustering, according to Dixon. In Canada, 300,000 are estimated to […]
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