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Nanopore Sequencing Applications: Past, Present, and Future Insights with Sissel Juul, VP of Applications

I reached the London Calling 2024 session for the “10 years of nanopore sequencing applications.” Sissel Juul, VP of Applications, spoke about what the technology has enabled. The applications team worked on inspiring the community, showcasing the technology, and driving applications. Now, Juul noted, the team works with the community. Since 2014, the technology has […]
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Joint Fragmentomic and Methylation Signatures of cfDNA for Cancer Detection by Billy Lau at London Calling 2024

Billy Lau from Stanford University returned to London Calling 2024 and spoke about “Joint fragmentomic and methylation signatures of cfDNA for cancer detection.” They began by defining liquid biopsies for non-invasive cancer measurement as typically being blood draws used for sequencing and multi-omic analyses. They also explained how epigenetic reprogramming in cancer occurs and how […]
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Methylomics and Fragmentomics: Pioneering Cancer Detection Models

Hanlee Ji from Stanford University presented at London Calling 2024 on “Genomic sequencing for characterizing tumor minimal residual disease versus early cancer.” Ji spoke about apoptosis and circulating tumor DNA. Ji and the team evaluated the recurrence of metastatic colorectal cancer with circulating DNA monitoring. Early detection of breast cancer can benefit from nanopore sequencing […]
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Epstein-Barr Virus and Methylation Patterns

Christopher Oakes from The Ohio State University spoke at London Calling 2019 on “Discerning the origin of Epstein-Barr virus in patients using nanopore-derived DNA methylation signatures.” Oakes spoke about how they study tumor viruses and cancer. The Epstein-Barr virus is common, the “prototypical cancer virus,” according to Oakes. Immune cells suppress the virus, but the […]
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Multi-modal Liquid Biopsy Analysis in Children with Cancer

Tonight I watched the London Calling 2023 session entitled “The potential application of nanopore sequencing for liquid biopsy analysis in children with cancer.” The second speaker was Carolin Sauer, a public research fellow at EMBL-EBI in the UK. Sauer focused on pediatric cancers and noted that they are the leading cause of death in the […]
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Deconvoluting Methylomes with Nanomix

Tonight I started watching videos from London Calling 2023! I started with the presentation by Jonathan Broadbent from the Ontario Institute for Cancer Research & the University of Toronto, Canada. Broadbent presented about “Nanomix: methylation-based cell-type deconvolution for low-pass nanopore sequencing.” They defined cell-free DNA (cfDNA) as “a mix of DNA from blood cells and […]
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Cell-free DNA Analyses for Acute Lymphoblastic Leukemia Treatment

Jessica Blackburn from the University of Kentucky spoke at the Nanopore Community Meeting 2021 about “Detection of cell-free DNA in acute lymphoblastic leukemia patients to potentially identify CNS disease and monitor response to therapy.” Blackburn explained that acute lymphoblastic leukemia is the most common pediatric cancer, with ~3,000 children diagnosed each year. They explained that […]
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CyclomicsSeq

jeroen de Ridder from Cyclomics and the University Medical Center Utrecht in the Netherlands presented “CyclomicsSeq: targeted and genome-wide detection of circulating tumor DNA using nanopore consensus sequencing” at London Calling 2022. They spoke about monitoring of treatment response and disease recurrence and avoiding invasive procedures. For this, they focused on cell-free tumor DNA: cfDNA […]
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