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Oxford Nanopore TB-DR Tuberculosis Drug Resistance Testing

Seanne P. Buckwalter from the Mayo Clinic spoke about “Rapid analysis of drug resistant M. tuberculosis complex” at London Calling 2024. The Mayo Clinic has numerous locations, and the three main ones, Buckwalter noted, are in the US. Buckwalter supports the mycobacteriology/mycology laboratory with fifty-six employees, nine BSL3 rooms, and over 48,000 mycobacterial cultures performed […]
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Methylomics and Fragmentomics: Pioneering Cancer Detection Models

Hanlee Ji from Stanford University presented at London Calling 2024 on “Genomic sequencing for characterizing tumor minimal residual disease versus early cancer.” Ji spoke about apoptosis and circulating tumor DNA. Ji and the team evaluated the recurrence of metastatic colorectal cancer with circulating DNA monitoring. Early detection of breast cancer can benefit from nanopore sequencing […]
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Nanopore Sequencing for mRNA Vaccine Quality Assurance

Helen Gunter from the BASE mRNA Facility at the University of Queensland in Australia spoke at London Calling 2024 on “Innovations in mRNA vaccine precision manufacturing.” BASE is the largest mRNA manufacturer in Australia, supplying commercial, government, and academic research labs. The plasmid is amplified, linearized, and used as a template to transcribe the mRNA. […]
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Discovering Deeply Intronic Mutations with Nanopore Sequencing

Tom Walsh from the University of Washington in the USA spoke at London Calling about “Discovery of deeply intronic damaging mutations with nanopore sequencing.” Walsh explained that in the 1990s, genetic testing for predisposition to breast cancer began. In the 200s, additional cancer-risk genes were discovered. Now, there are numerous panels and ten genes for […]
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Flames and Blaze: Advancing Long-Read scRNA-seq for Brain Development Research

Mike Clark from The University of Melbourne in Australia presented at London Calling 2024 on “Igniting single-cell analysis of full-length RNA isoforms in brain development.” Clark works on RNA isoforms and developing single-cell analysis methods. They noted that almost all human genes express multiple RNA isoforms. Clark emphasized that alternative splicing modifies which exons are […]
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Understanding Drug Resistance in Multiple Myeloma: Insights from Tomas di Domenico

Tonight, I watched Tomas di Domenico from the National Cancer Research Center in Spain present at London Calling 2024 on “An (epi-)genomics analysis of drug resistance in multiple myeloma.” Di Domenico explained how multiple myeloma affects the bone marrow and thickens the blood. Multiple myeloma also causes bone issues. There are several treatments and a […]
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Long-Read Sequencing Innovations in Neurodegenerative Disease Research

Tonight, I watched the London Calling 2024 session on “breaking boundaries in neurodegenerative disease research.” Cora Vacher from Oxford Nanopore Technologies (ONT) introduced the speakers and facilitated the question and answer session. Joanne Trinh from the Institute of Neurogenetics at the University of Lubeck in Germany was the first presenter. Trinh works with a research […]
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The Significance of Long Reads in Determining Intronic Mutations

Today, I watched another London Calling 2024 studio interview. Zoe McDougall interviewed three speakers. Tom Walsh from the University of Washington spoke about how long reads are important to determine intronic mutations. The full locus of BRCA1 is over 100 kb, and intronic mutations can occur with significant implications. Mike Clark from the University of […]
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Oxford Nanopore Technologies Innovations for Rapid Tumor Classification – London Calling 2024

The London Calling 2024 studio interview session I watched tonight was about rapid tumor classification. Zoe McDougall spoke to Simon Paine from Nottingham University Hospitals NHS Trust in the UK. Paine is a neuropathologist and analyzes samples to predict patient outcomes. They are excited about discovering ways to classify tumors using Oxford Nanopore Technologies. The […]
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Telomeres, Cell-free RNAs, and On-site Sequencing

Tonight, I watched the London Calling 2024 studio interview about innovations in conservation and RNA in liquid biopsy. Zoe McDougall interviewed three researchers about conservation genomics and the accessibility of the technologies. Mrinalini Wasta from the San Diego Zoe Wildlife Alliance spoke about the challenges of taking samples from outside communities and involving partners. The […]
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