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Understanding Isoform Diversity in the Mouse Retina

Tonight, I watched a session on single-cell and spatial transcriptomics methods. The Oxford Nanopore Technologies (ONT) introduction highlighted how adding more cells increases resolution, yet short-read approaches have limits. Emphasizing the tagline “What’s missing matters,” the speaker noted that isoform switching is important to identify. The ONT specialist explained several solutions compatible with ONT, including […]
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Flames and Blaze: Advancing Long-Read scRNA-seq for Brain Development Research

Mike Clark from The University of Melbourne in Australia presented at London Calling 2024 on “Igniting single-cell analysis of full-length RNA isoforms in brain development.” Clark works on RNA isoforms and developing single-cell analysis methods. They noted that almost all human genes express multiple RNA isoforms. Clark emphasized that alternative splicing modifies which exons are […]
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