Tonight, I watched the London Calling 2024 session about EPI2ME workflows. The title was “Product demo: Integrated EPI2ME: streamlined analysis for clinical and biopharma applications.” Matt Parker from ONT is a clinical scientist. They spoke about AmPORE-TB, human variation workflows, and mRNA vaccine quality control. The tuberculosis workflow aims to rapidly identify antimicrobial resistance in […]
Trish Simner is the Director of Bacteriology and Infectious Disease Sequencing Laboratories. They work at the Johns Hopkins University School of Medicine in Baltimore, Maryland. They presented at London Calling 2024. The session’s title was “Bringing Nanopore Sequencing into the Clinical Microbiology Setting with Targeted Approaches.” Simner spoke about the advantages of long reads and […]
I watched a session from the Oxford Nanopore Technologies Clinical & Biopharma Day tonight. It was held on May 24, 2024 (part of London Calling 2024). Professor Pieter Wesseling is from the Princess Maxima Center for Pediatric Oncology in the Netherlands. He is also from the Amsterdam University Medical Centers. He presented the session titled […]
Bosheng Li from the Institute of Advanced Agricultural Sciences of Peking University in China presented at London Calling 2024. The session’s title was “Plant T2T genome assembly using ultra-long and adaptive nanopore sequencing.” They spoke about the importance of ultra-long reads. These reads produce N50 length >100 kb. These are crucial in the assembly of […]
Alexander Wittenberg from KeyGene in the Netherlands spoke at London Calling 2024 about “Unlocking the banana pangenome: harnessing genetic diversity.” They explained that the genetic diversity of bananas is very low because of the passaging of a single clone. Fusarium wilt and black Sigatoka cause disease and elicit the spraying of large amounts of pesticides. […]
Sarah Cameron from the University of Bath presented at London Calling 2024 a short session with the title “100 years of Bordetella pertussis evolution in the UK.” They noted that we have had a vaccine for Bordetella for decades and it changed to an acellular version in 2001. The genome of this organism varies through […]
Oscar Enrique Torres Montaguth from the University College London in the UK presented a short talk at London Calling. The title was “Genomic studies of adeno-associated virus hepatitis.” They studied the 2022 pediatric hepatitis outbreak using metagenomic sequencing approaches. They identified AAV2 in liver and blood samples of almost all cases, and adenoviruses and herpesviruses […]
Matthew Jones from Stanford University presented at London Calling 2024 a session titled “CoRAL accurately resolves extrachromosomal DNA structures with long-read sequencing.” This toolkit can be used to study extrachromosomal or ecDNA, a form of oncogene amplification in cancers. ecDNA is not found in normal cells, is associated with shorter patient survival, and is large: […]
Guillaume Cogan from the Paris Brain Institute in France and the National Institutes of Health in the US presented at London Calling 2024 on “Long-read sequencing to solve exome negative Parkinson’s disease.” Cogan explained that genetics and environmental susceptibility factors contribute to 90% of Parkinson’s disease in patients. However, 10% of patients have autosomal dominant […]
I am preparing to go to Seattle tomorrow to visit the Allen Institute again! Tonight I watched Ronja Friedhoff from the Technische Universitat Braunschweig in Germany present at London Calling 2024. The title of the session is “Accessing the biosynthetic gene repertoire of medicinal plants.” Friedhoff started by asking, “What secrets are hidden in plant […]