vaccine

mRNA Vaccine Quality Control with Nanopore Sequencing

Helen Gunter from The BASE Facility of The University of Queensland in Australia presented at the ONT Biopharma Day. The session’s title was “Using nanopore sequencing for mRNA vaccine quality control: a journey from R&D to GMP.” They noted that since the COVID vaccines, there has been interest in synthetic mRNAs. Gunter spoke about the […]
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BioNTech’s mRNA Innovations: Fighting Diseases Effectively

Andreas Czech from BioNTech in Germany presented at the Biopharma Day in Boston on “The potential of therapeutic mRNA—and how to measure it.” They spoke about the vision of the BioNTech pharmaceutical company: to use the immune system’s power to fight cancer and other diseases. The company was founded in 2008 by three tumor immunologists. […]
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Uncovering Vaccine Resistance: Genome Sequencing of 198 UK Bordetella Pertussis Strains

Sarah Cameron from the University of Bath presented at London Calling 2024 a short session with the title “100 years of Bordetella pertussis evolution in the UK.” They noted that we have had a vaccine for Bordetella for decades and it changed to an acellular version in 2001. The genome of this organism varies through […]
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Nanopore Sequencing for mRNA Vaccine Quality Assurance

Helen Gunter from the BASE mRNA Facility at the University of Queensland in Australia spoke at London Calling 2024 on “Innovations in mRNA vaccine precision manufacturing.” BASE is the largest mRNA manufacturer in Australia, supplying commercial, government, and academic research labs. The plasmid is amplified, linearized, and used as a template to transcribe the mRNA. […]
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VAX-seq for mRNA Vaccine Quality Analysis

Helen Gunter from the Australian Institute for Bioengineering and Nanotechnology at the University of Queensland in Australia spoke at London Calling 2023 about “Using nanopore sequencing to understand the manufacture, delivery, and action of mRNA vaccines.” Gunter explained how they use Oxford Nanopore Technologies devices and sequencing in vaccine development. They spoke about the mRNA […]
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Porcine Respiratory Disease Diagnostics

Nick Vereecke from PathoSense BV in Belgium presented at London Calling 2023 on “Coninfection in endemic influenza A virus-infected herds using nanopore metagenomic sequencing of tracheobronchial swabs.” Vereecke spoke about the complexity of porcine respiratory diseases: there is a mix of coronaviruses and bacteria. For some of the microbes involved, there are no lab culture […]
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Malaria Surveillance with Nanopore Sequencing

We are at the beach! What a week! Tonight I watched William Hamilton from the Wellcome Sanger Institute in the UK speak at London Calling 2023 on “Nanopore sequencing for real-time genomic surveillance of Plasmodium falciparum.” They are applying Nanopore sequencing to surveillance of malaria, assay development in Ghana, and training. Hamilton described malaria as […]
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