I started watching the on-demand lighting talk recordings from London Calling 2023 tonight. I started with Camille Mumm’s session. Mumm is from the University of Michigan and presented on “Exploring the impact of mobile elements on Alzheimer’s disease using targeted long-read sequencing.”Mumm is also a graduate student (at the time of recording). They spoke about characterizing mobile elements and their impact on Alzheimer’s disease. They were interested in studying somatic mutations and mobile element insertions (MEI). The research team used targetted sequencing and adapted the Nanopore Cas9-targeted sequencing (nCATS) for mobile element insertions for elements active in the human genome. They sequenced several regions from patient and control samples. Mumm shared preliminary data depicting the coverage tracks for Alu insertions. This approach allows for the sequencing of mobile elements and the study of methylation patterns.
