Month: September 2023

Dynamic Adaptive Sampling

Tonight I continued watching the London Calling 2023 Showcase Stage recordings for sessions on targeted sequencing. The speaker was Lukas Weilguny a Ph.D. student from the EMBL-EBI in the UK. The title of the session was “Dynamic, adaptive sampling during nanopore sequencing using Bayesian experimental design.” They worked on a model that takes the sequencing […]
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Sequencing and Assembly of an Endangered Tortoise Genome

Tonight I watched the Oxford Nanopore Technologies (ONT) London Calling 2023 Showcase Stage on Conservation. In this session, Luca Pandolfini from the Italian Institute of Technology in Italy presented “From genome assembly to epigenome characterisation: a nanopore journey in the footsteps of an endangered tortoise.” Pyxis arachnoides is a tiny tortoise that is critically endangered […]
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Medical Mysteries and CRISPR-Cas9 Nanopore Diagnostics

Cecilia C.S. Yeung & Olga Sala-Torra from the Fred Hutchinson Cancer Center presented the session “Potential clinical utility of long-read sequencing in myeloid neoplasms.” They are both clinicians and saw the potential of long-read sequencing for detection of myeloid neoplasms. The assay has the potential to rapid detect cytogenetic aberrations. Sala-Torra spoke about how fusions […]
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A Bed File to Create a Molecular Diagnostic Panel for Germline Cancer Predisposition

Tonight I continued watching the London Calling 2023 targeted sequencing showcase. In the four-minute recording entitled “The potential use of nanopore sequencing for molecular diagnosis of germline cancer predisposition,” Romain Boidot from the Centre Georges-François Leclerc in France spoke about their use of Oxford Nanopore Technologies (ONT) for molecular diagnosis and sequencing. Their current analysis […]
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Clinicians and Bioinformaticians Using Nanopore for Diagnostics

Tonight I watched the London Calling 2023 panel “The future of clinical genomics.” Four panelists were asked several questions. The first was about the role of bioinformaticians in clinical work. One panelist spoke about how clinicians work on the automation and presenting the data. The exchange with bioinformaticians has helped the clinicians make the most […]
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aPOG and Long-read Sequencing

Janessa Laskin from Canada’s Michael Smith Genome Sciences Centre at BC Cancer presented at London Calling 2023 on the “Potential use of nanopore sequencing in clinical cancer genomics.” Laskin is a clinician and medical oncologist. They spoke about the uncertainty of what treatments to select for patients and the idea of personalized medicine. Laskin explained […]
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Liquid Biopsies for Longitudinal Non-invasive Cancer Monitoring

Tonight we started our first P2 run with two PromethION flow cells. I also continued watching the London Calling 2023 Showcase Stage on liquid biopsy. I watched them out of order! Today I watched Billy Lau from Stanford University School of Medicine do a quick presentation titled “Nanopore sequencing of cell-free DNA for methylation-based breast […]
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Better Libraries and Improved Sequencing for Liquid Biopsy Samples

I continued watching the London Calling 2023 Showcase Stage sessions on liquid biopsies today. I watched the question and answer session. Panelists spoke about using amplicon panels and the Flongle. One panelist uses amplicon sequencing with Nanopore devices because they are able to go from sample to results in under eight hours. Another panelist answered […]
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