Month: June 2025

Revolutionizing Infectious Disease with EIT and Oxford Nanopore

Emma Stanton from the Ellison Institute of Technology (EIT) in the UK presented at London Calling 2025 on “EIT Pathogena and Oxford Nanopore Technologies revolutionising infectious disease.” Stanton started as a medical doctor and spoke about interdisciplinary teams driving impacts for patient care. The Ellison Institute of Technology was envisioned by a co-founder of Oracle. […]
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Understanding Vancomycin-Resistant _E. faecium_ Transmission in New Zealand

Rhys White from the Institute of Environmental Science and Research in New Zealand presented at London Calling 2025. The title of the session was “Nanopore sequencing captures first in-patient evolution of vancomycin-resistant E. faecium in New Zealand.” White explained that Enterococcus faecium lives in the human gut and is a Gram-positive opportunistic pathogen. White and […]
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Creating a Tonsil Atlas to Study Lymphocytic Leukaemia

Ivo Gut from the National Centre for Genomic Analysis in Spain presented at London Calling 2025 on “Going the extra mile to understand chronic lymphocytic leukaemia.” Gut explained that they wanted to focus on single-cell RNA-seq during leukemia and proposed studies to the European Research Commission. The team had preliminary data indicating two distinct clusters […]
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Challenges in Diagnosing Pediatric Leukemias in Low-Income Countries

Javeria Aijaz from the Indus Hospital and Health Network in Pakistan presented at London Calling 2025 on “Pediatric leukemias: clinical validation of Oxford Nanopore-based gene expression profiling.” Aijaz explained that pediatric leukemias are divided into three lineages. Classification often requires flow cytometry. WHO introduced the category of “Not Further Classified” (NFC). Currently, comprehensive diagnosis requires […]
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Insights on CAR T-Cell Resistance through Single-Cell Sequencing

Ruben Cools from VIB-KU Leuven, Belgium presented at London Calling 2025 on “Bridging genotype and phenotype through long-read, single-molecule multiomics.” They are working on a high-throughput long-read single-cell open chromatin and transcriptome profiling method. The SPLOGGET approach prepares whole-genome, open chromatin and full-length transcriptome sequencing libraries for single cells. Cools explained that the method uses […]
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Using Oxford Nanopore Technologies for Cancer Diagnosis in Low-Resource Settings

Thomas Alexander from the University of North Carolina spoke at London Calling 2025 about “Collaborative development of pediatric cancer diagnostics in low-resource settings.” Alexander is a physician and focused on the use of Oxford Nanopore Technologies (ONT) to diagnose cancers. Diagnostic accuracy is foundational, and low-resource countries have worse outcomes, noted Alexander. Using a single […]
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Improving Drinking Water Safety with Phage Research

Tonight I am in Seattle for the Allen Institute Open Science conference. I watched Rachel Samson P. from Cranfield University in the UK present on “Mapping coliphage diversity for next-generation drinking water security through the nanopore lens.” Samson gained expertise from graduate work to measure water quality and described using coliphage diversity as a proxy. […]
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Advancing Pediatric Germ Cell Tumor Classification

Ana Flavia is a PhD student at Barretos Cancer Hospital, Brazil, and also a visiting scholar at The University of North Carolina at Chapel Hill. Flavia presented at London Calling 2025 on “Advancing pediatric germ cell tumor classification through nanopore-based transcriptome analysis.” Germ cell tumors (GCT) were described as rare and diagnosed by morphological classification […]
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Advancements in Nanopore HLA Testing for Pharmacogenomics

Thidathip Wongsurawat presented at London Calling 2025 on “Nanopore-based HLA testing: a rising star driving real-world clinical implementation in pharmacogenomics.” Wongsurawat is from Mahidol university in Thailand. Wongsurawat has been using nanopore sequencing since 2017 and moved back to her hometown after doing research in the US. Now they work with a company and set […]
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Nanopore Sequencing in Clinical Settings: Insights from UMC Utrecht

Marcel Nelen from the UMC Utrecht in the Netherlands, spoke at London Calling 2025 on “Nanopore sequencing: a newbie’s perspective on needs in a clinical setting.” The Genome Diagnostics section at UMC Utrecht is a genome diagnostic center that works under ISO accreditation. All the tests are accredited by the Dutch accreditation council. Nelen noted […]
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