Carlos C. Goller

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Understanding Alternative Splicing with Blessy R Package

Nadia Davidson from The Walter and Eliza Hall Institute in Australia presented at London Calling 2025. The intriguing title of the session was “Blessy: enabling differential analysis of phased protein domains.” Blessy is a new tool from Davidson’s research group. Davidson spoke about the impact of alternative splicing on protein function. Davidson and team used […]
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Advancements in Antisense Oligonucleotide Design

Joy Goffena from the University of Washington presented at London Calling 2025. The title of the session was “Variant phasing for antisense oligonucleotide design using adaptive sampling.” Goffena explained antisense oligonucleotide (ASO) technology as short DNA or RNA that can bind target RNA to block translation or even modulate splicing. The goal of their work […]
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Ultra-Fast Classifiers for Pediatric Tumors: Insights from Lennart Kester

I am back from SABER and getting settled. Tonight I watched Lennart Kester from the Princess Maxima Center in The Netherlands present on “Ultra-fast deep-learned classification algorithms for diagnosing pediatric CNS and solid tumors” at London Calling 2025. Kester explained that over the years they have observed an increase in the number of tumor entities, […]
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Decoding the Epitranscriptome: Innovative Approaches in rRNA Modifications

Eva Maria Novoa from the Centre for Genomic Regulation in Spain presented at London Calling 2025 on “Decoding the epitranscriptome at single-molecule resolution: towards clinical applications.” Novoa spoke about ribosomal RNA modifications. They study ribosomal RNA modifications. There are more than 12 modifications in rRNA. The new generation of algorithms allows the detection of more […]
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Efficient Genome Assembly with Hifiasm

Haoyu Cheng from Yale University spoke at London Calling 2025 on “Efficient telomere-to-telomere genome assembly with nanopore reads using hifiasm.”Cheng described the challenges of assembling a diploid human genome. In 2022, the first telomere-to-telomere (T2T) human genome was published. One current strategy is to use long-read data and phasing. There are computational challenges. Hifiasm is […]
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Comparing Illumina and ONT for Genome Analysis

After a good vacation in San Miguel de Allende, Mexico, I am back! Tonight I watched Michael Wiley from the University of Nebraska Medical Center in the USA present at London Calling 2025 on “Automated sample-to-answer workflows for whole genome sequencing to investigate hospital-acquired infections.” The public health labs are embedded in the medical center […]
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Revolutionizing Infectious Disease with EIT and Oxford Nanopore

Emma Stanton from the Ellison Institute of Technology (EIT) in the UK presented at London Calling 2025 on “EIT Pathogena and Oxford Nanopore Technologies revolutionising infectious disease.” Stanton started as a medical doctor and spoke about interdisciplinary teams driving impacts for patient care. The Ellison Institute of Technology was envisioned by a co-founder of Oracle. […]
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Understanding Vancomycin-Resistant _E. faecium_ Transmission in New Zealand

Rhys White from the Institute of Environmental Science and Research in New Zealand presented at London Calling 2025. The title of the session was “Nanopore sequencing captures first in-patient evolution of vancomycin-resistant E. faecium in New Zealand.” White explained that Enterococcus faecium lives in the human gut and is a Gram-positive opportunistic pathogen. White and […]
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Creating a Tonsil Atlas to Study Lymphocytic Leukaemia

Ivo Gut from the National Centre for Genomic Analysis in Spain presented at London Calling 2025 on “Going the extra mile to understand chronic lymphocytic leukaemia.” Gut explained that they wanted to focus on single-cell RNA-seq during leukemia and proposed studies to the European Research Commission. The team had preliminary data indicating two distinct clusters […]
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Challenges in Diagnosing Pediatric Leukemias in Low-Income Countries

Javeria Aijaz from the Indus Hospital and Health Network in Pakistan presented at London Calling 2025 on “Pediatric leukemias: clinical validation of Oxford Nanopore-based gene expression profiling.” Aijaz explained that pediatric leukemias are divided into three lineages. Classification often requires flow cytometry. WHO introduced the category of “Not Further Classified” (NFC). Currently, comprehensive diagnosis requires […]
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