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Flames and Blaze: Advancing Long-Read scRNA-seq for Brain Development Research

Mike Clark from The University of Melbourne in Australia presented at London Calling 2024 on “Igniting single-cell analysis of full-length RNA isoforms in brain development.” Clark works on RNA isoforms and developing single-cell analysis methods. They noted that almost all human genes express multiple RNA isoforms. Clark emphasized that alternative splicing modifies which exons are […]
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Genomic Surveillance of Multi-Drug Resistant Organisms with Long-Read Sequencing

Today was the first day of our IPERT Summer Workshops! I also started watching London Calling 2024 videos available on the YouTube channel. I began with the session titled “Genomic surveillance of multidrug-resistant organisms based on long-read sequencing.” Fabian Landman works at the Centre for Infectious Disease Control in The Netherlands and the Dutch National […]
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Oxford Nanopore Technologies Innovations for Rapid Tumor Classification – London Calling 2024

The London Calling 2024 studio interview session I watched tonight was about rapid tumor classification. Zoe McDougall spoke to Simon Paine from Nottingham University Hospitals NHS Trust in the UK. Paine is a neuropathologist and analyzes samples to predict patient outcomes. They are excited about discovering ways to classify tumors using Oxford Nanopore Technologies. The […]
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Portable Lab for Wastewater DNA Extraction

Tonight, I started watching sessions from London Calling 2024! Rea Kobialka from the Institute of Animal Hygiene and Veterinary Public Health in Germany presented a session entitled “Mobile lab for rapid detection of pathogens in wastewater in sub-Saharan Africa.” They emphasized the importance of surveillance. The research team developed a portable suitcase mobile lab. The […]
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Whole Genome Plasmid Sequencing

Tonight, I watched a recent Oxford Nanopore Technologies video about plasmid sequencing. The title is “A new and improved ‘gold standard’ for complete plasmid verification.” This session was a Knowledge Exchange with Aaron Pomerantz, Segment Marketing Manager at ONT. They spoke about plasmids and their use in molecular biology and industrial processes. Sanger sequencing has […]
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Improving Detection of Cancer Mutations with CyclomicsSeq

Tonight I watched Jeroen de Ridder from the University Medical Center Ultrecht in the Netherlands present at London Calling 2019. They spoke about “Cyclomics: ultra-sensitive nanopore sequencing of cell-free tumor DNA.” Ridder spoke about the importance of detecting the recurrence of cancer in patients. Common diagnostics may not be suitable, and liquid biopsies of the […]
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RAGE-seq and CITE-seq

Martin Smith from the Garvan Institute of Medical Research in Australia was mentioned in the London Calling 2019 session I watched yesterday. Today, I watched the recording of the 2019 London Calling session that Smith did on “Leveraging long reads for high-throughput multiomic analyses of cellular diversity in human tumours.” Smith wasn’t able to travel, […]
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Nonsense-mediated Decay of mRNAs

Evangelos Karousis from the University of Bern in Switzerland presented at London Calling 2019 on “Splice isoform-specific analysis of endogenous NMD targets in human cells.” Karousis explained that RNA degradation is involved in various biological functions, and nonsense-mediated decay (NMD) is not well understood. Nonsense mRNA is dangerous because it can contribute to disease. NMD […]
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