haplotypes

KeyGene’s Innovative Approach to Banana Pangenome Research

Alexander Wittenberg from KeyGene in the Netherlands spoke at London Calling 2024 about “Unlocking the banana pangenome: harnessing genetic diversity.” They explained that the genetic diversity of bananas is very low because of the passaging of a single clone. Fusarium wilt and black Sigatoka cause disease and elicit the spraying of large amounts of pesticides. […]
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MethPhaser and Improved Haplotype Phasing of Human Genomes

“MetaPhaser: methylation-based haplotype phasing of human genomes” is the title of the NCM Houston session I watched tonight. Yilei Fu from Rice University was the presenter. They began sharing how long reads provide more information about structural variations (SV) and help with assembly and phasing. Fu explained an example of thiopurine methyltransferase (TMPT) and how […]
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Improving Phasing Methods

What a busy day! We tried VolTRAX and Miro library preps today as part of the PORES workshop. We also did DNA extractions, a Miroculus workshop, and lots of moving around. Tonight I watched the London Calling 2023 session entitled “MethPhaser: automated methylation-based haplotype phasing of human genomes with Oxford Nanopore sequencing” with Fritz Sedlazeck […]
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Cas9 Enrichment for KIR Haplotype Analysis

Tonight I watched the Nanopore Community Meeting 2021 session by Jesse Bruijnesteijn from the Biomedical Primate Research Center in the Netherlands. Their session was entitled “Rapid characterization of complex killer cell immunoglobulin-like receptor regions using Cas9 enrichment and nanopore sequencing.” They began by explaining the role of NK cell activation in recognizing inhibitory and activating […]
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AmplideX PCR and Nanopore Sequencing for Carrier Screening

Sarah Statt presented at the Nanopore Community Meeting 2021 on “AmplideX PCR and nanopore sequencing deepens analysis and simplifies workflows for carrier screening.” Statt is an R&D Senior Manager at Asurgen, a Bio-Techne Brand. They spoke about the technologies needed for carrier screening. The company created AmplideX that includes long-range PCR and long-read sequencing to […]
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