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Feasibility of Rapid Respiratory Metagenomic Sequencing for ICU Patients

Gaia Nebbia from the Guy’s and St. Thomas’ NHS Foundation Trust in the UK presented at London Calling 2024. The session focused on respiratory metagenomics in clinical service. This study explored metagenomic sequencing for respiratory infection control and diagnostics. The team identified areas of improvement for the identification of viral sequences. The aim of the […]
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Nanopore Sequencing Applications: Past, Present, and Future Insights with Sissel Juul, VP of Applications

I reached the London Calling 2024 session for the “10 years of nanopore sequencing applications.” Sissel Juul, VP of Applications, spoke about what the technology has enabled. The applications team worked on inspiring the community, showcasing the technology, and driving applications. Now, Juul noted, the team works with the community. Since 2014, the technology has […]
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Public Health Showcase 2024: One Health Genomics and Nanopore Sequencing

Tonight, I watched the London Calling 2024 Public Health Showcase. Associate Director of Global Segment Marketing Aaron Pomerantz helped moderate the session. Lara Urban from Helmholtz AI in Germany was the first speaker. Urban described the connections between One Health Genomics and Nanopore sequencing. One Health Policy was addressed with air microbiome to assess the […]
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Direct Sequencing of Cytosine Modification States from Nanopore Long-Read Data

Dominic Halliwell from the University of Bath in the UK presented at London Calling 2024 on “Direct sequencing of cytosine modification states from nanopore long-read data.” They are a doctoral student and were partially funded by Oxford Nanopore Technologies (ONT). Halliwell spoke about 5mC, 5hmC, and later oxidation derivatives, emphasizing that genome methylation can be […]
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Advancing Cancer Detection with RNA Liquid Biopsies

Daniel Kim from the University of California, Santa Cruz, presented at London Calling 2024. The session was on “Advancing RNA liquid biopsy technology via nanopore sequencing.” The Kim lab is working on advancing cancer detection with liquid biopsies. RNA is secreted into the circulation in extracellular vesicles (EVs). Kim noted that EVs can protect RNA. […]
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CariGenetics: Innovating Genomic Sequencing with PromethION in Bermuda

Tonight, I watched the London Calling 2024 product demo. The title of the session was “From sample to insight: exploring human genomics with PromethION end-to-end sequencing solutions.” Rachel Rubinstein, a Technical Product Manager with ONT, was the moderator. They explained that with a single PromethION flow cell, you can obtain 100-200 Gbases of data and […]
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Enhancing Acute Care in New Zealand Through Nanopore Sequencing

Justin O’Sullivan from the Liggins Institute at the University of Auckland in New Zealand presented at London 2024. The session’s title was “Establishing a nanopore sequencing facility for acute care in New Zealand.” They spoke about closing the borders during the pandemic. Being an island, they can control entrance and exit from the country more […]
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Unveiling the Potential of Long-Read Sequencing in Newborn Screening

Tonight, I watched Cate Paschal from the Seattle Children’s Hospital. They spoke about “Exploration of long-read sequencing in the resolution of newborn screening.” This was a London Calling 2024 session. Paschal spoke about newborn screening as a diagnostic test for rare diseases. Paschal explained that Pompe disease is a glycogen storage disorder with a prevalence […]
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HERRO: Haplotype-Aware Error Correction of Ultra-Long Nanopore Reads by Mile Sikic

Mile Sikic from the Genome Institute of Singapore spoke at London Calling 2024. The session’s title was “HERRO: haplotype-aware error correction of ultra-long nanopore reads.” Sikic noted that HERRO can be used for any type of Nanopore reads. They developed Racon seven years ago. Now, there are phased genomes, and the challenge is to maintain […]
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