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Databases and Sequencing to Reveal the Microbiome of Wastewater Treatment Plants

Tong Zhang from The University of Hong Kong presented at London Calling 2019 on “Mobile antibiotic resistome in wastewater treatment plants revealed by nanopore metagenomic sequencing.” Zhang explained that the work was mainly performed by a student in their research group. The impact of environmental resistance was emphasized with the prevalence of antibiotic resistance genes […]
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Blood Cancer Detection

Tonight, I watched the London Calling 2019 session by Anna Schuh from the University of Oxford in the UK. The title of the presentation was “Global applications of nanopore sequencing in clinical haematology.” Schuh explained that blood cancers are challenging to treat and that patients would benefit from precision medicines. Chronic myeloid leukemia was the […]
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A Map of the Human X Chromosome

Karen Miga from the University of California, Santa Cruz, presented at London Calling 2019 on “Telomere-to-telomere assembly of a complete human X chromosome.” Miga is part of the Telomere-to-Telomere Consortium. They spoke about the gaps in the human genome. The challenge of assembling repeat regions may be tackled with ultra-long reads. Using the Josh Quick […]
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Improving Detection of Cancer Mutations with CyclomicsSeq

Tonight I watched Jeroen de Ridder from the University Medical Center Ultrecht in the Netherlands present at London Calling 2019. They spoke about “Cyclomics: ultra-sensitive nanopore sequencing of cell-free tumor DNA.” Ridder spoke about the importance of detecting the recurrence of cancer in patients. Common diagnostics may not be suitable, and liquid biopsies of the […]
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RAGE-seq and CITE-seq

Martin Smith from the Garvan Institute of Medical Research in Australia was mentioned in the London Calling 2019 session I watched yesterday. Today, I watched the recording of the 2019 London Calling session that Smith did on “Leveraging long reads for high-throughput multiomic analyses of cellular diversity in human tumours.” Smith wasn’t able to travel, […]
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GRAID to Facilitate Technology Transfer and Training

Tonight, I watched the recording of Lucky Ronald Runtuwene from the University of Tokyo in Japan from London Calling 2019. Runtuwene is part of a sequencing core at a university campus. They have several Illumina devices and a PromethION. Their goal is to expedite research in developing countries. They started a collaboration with Indonesia, starting […]
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Detection of RNA Modifications

Eva Maria Novoa from the Center for Genomic Regulation in Spain presented at London Calling 2019 a session on “Accurate detection of m6A RNA modification in native RNA sequences using third-generation sequencing.” Novoa emphasized there is a difference between RNA levels and protein. They have been working in this field. Interestingly, RNA modifications have been […]
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Nonsense-mediated Decay of mRNAs

Evangelos Karousis from the University of Bern in Switzerland presented at London Calling 2019 on “Splice isoform-specific analysis of endogenous NMD targets in human cells.” Karousis explained that RNA degradation is involved in various biological functions, and nonsense-mediated decay (NMD) is not well understood. Nonsense mRNA is dangerous because it can contribute to disease. NMD […]
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