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Development of a Nanopore-friendly Carrier Screening Test

I started watching the “Onsite lighting talks at London Calling 2023” playlist. Bradley Hall from Asuragen in the USA presented “The dark side of carrier screening: illuminating hard-to-decipher genes in common genetic disorders with nanopore sequencing.” Hall explained how carrier screening has evolved and the number of gene targets included in different screens. Hall emphasized […]
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Detecting the Epigenome with ONT

Chen Yong from Oxford Nanopore helped facilitate the Knowledge Exchange session I watched tonight: “Decoding the epigenome with Oxford Nanopore real-time methylation detection.” This webinar was recorded. Sayonika Mohanta from ONT explained that methylation is central to gene expression. They spoke about the role of methylation in gene expression: her or hypo methylation can affect […]
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Rapid Chromosome Evolution in Gibbons

Gabrielle Hartley from the University of Connecticut presented at London Calling 2023 a lightning talk. The session’s title is “Telomere-to-telomere nanopore-based genome assembly reveals genomic and epigenetic features of karyotype radiation.” Hartley is a graduate student and is studying the evolution of gibbons. They noted that, unlike other apes, gibbons “have highly rearranged karyotypes concomitant […]
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Use of Long-read Sequencing in a Contract Food Laboratory

Andrzej A. Benkowski from Eurofins Microbiology Laboratories in Madison, WI, presented at London Calling 2023 a lightning talk on the “Practical uses of nanopore long-read sequencing in a high-throughput contract food laboratory.” They presented a few case studies from the contract lab. The first case study was from a client who experienced an increase in […]
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Mitochondrial Genome Sequencing Reveals Variants

“Single-cell full-length nanopore sequencing for quantitative variant analysis of native and genome-edited mitochondria” is the title of the London Calling 2023 lightning talk I watched tonight. The presenter was Mo Li from King Abdullah University of Science and Technology (KAUST) in Saudi Arabia. Li spoke about the human mitochondrial genome (mtDNA) and the challenges in […]
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Highly Multiplex Aptamer-based Biomarker Detection with ONT

Caroline Koch from the Imperial College in London, UK, presented at London Calling 2023 a lightning talk on “Novel screening platform for highly multiplexed biomarker analysis.” Koch was a Ph.D. student and explained why we need methods for multiplexed biomarker detection by emphasizing how we all express diseases differently and need sensitive diagnostic methods. They […]
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Studying Centromere Structure with ONT

I continue to watch the YouTube “Assembly” playlist from the Oxford Nanopore Technologies (ONT) channel. Tonight, I watched session #8! Ian Henderson from the University of Cambridge in the UK presented at the Nanopore Community Meeting 2021. The session was titled “Assembling the centromeres – the ‘black holes’ of the genome.” Henderson said the centromeres […]
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CanSeq150 to Sequence Canada’s Most Endangered Species

The London Calling 2021 session “CanSeq150: high-resolution genomic sequencing and assembly of 150 Canadian species” caught my attention today. Jahanshah Ashkani from Canada’s Michael Smith Genome Sciences Center was the speaker. The goal is to save Canada’s rich biodiversity by sequencing unique species. Loss of biodiversity is an issue: there are over 700 species at […]
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Sequencing a Fungal Banana Pathogen

Luca Degradi from the University of Milan in Italy presented at London Calling 2021 about “Chromosome-level genome assembly of Fusarium musae using MinION.” They described this organism as a “cross-kingdom pathogen” reported by the HUPLANTcontrol program in Europe. The organism can infect bananas and humans! The first infection seems to have been a human. At […]
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