NMD

Nonsense-mediated Decay of mRNAs

Evangelos Karousis from the University of Bern in Switzerland presented at London Calling 2019 on “Splice isoform-specific analysis of endogenous NMD targets in human cells.” Karousis explained that RNA degradation is involved in various biological functions, and nonsense-mediated decay (NMD) is not well understood. Nonsense mRNA is dangerous because it can contribute to disease. NMD […]
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Direct RNA Sequencing Identifies NMD Targets

Anna Glushkevich from the Shmyakin-Ovchinnikov Institute of Bioorganic Chemistry in the Russian Federation, presented at the Nanopore Community Meeting 2021 on “Direct RNA sequencing reveals unusual NMD targets in plants.” They study nonsense-mediated RNA decay (NMD), a mechanism that regulates up to 10% of cellular transcripts! This is the second time I hear about Nanopore […]
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Long-read Sequencing Can Identify RNA Isoforms and NMD Modulators

Evangelos Karousis is a Senior Researcher at the University of Bern, Switzerland and presented at the Nanopore Community Meeting 2021 on “Nanopore sequencing reveals endogenous NMD-targeted isoforms in human cells.” They began by describing what nonsense-mediated mRNA decay (NMD) can do how how they can be dangerous. Endogenous mRNAs can be targeted by NMD. In […]
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