sequencing

Advancements in Antisense Oligonucleotide Design

Joy Goffena from the University of Washington presented at London Calling 2025. The title of the session was “Variant phasing for antisense oligonucleotide design using adaptive sampling.” Goffena explained antisense oligonucleotide (ASO) technology as short DNA or RNA that can bind target RNA to block translation or even modulate splicing. The goal of their work […]
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Ultra-Fast Classifiers for Pediatric Tumors: Insights from Lennart Kester

I am back from SABER and getting settled. Tonight I watched Lennart Kester from the Princess Maxima Center in The Netherlands present on “Ultra-fast deep-learned classification algorithms for diagnosing pediatric CNS and solid tumors” at London Calling 2025. Kester explained that over the years they have observed an increase in the number of tumor entities, […]
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Decoding the Epitranscriptome: Innovative Approaches in rRNA Modifications

Eva Maria Novoa from the Centre for Genomic Regulation in Spain presented at London Calling 2025 on “Decoding the epitranscriptome at single-molecule resolution: towards clinical applications.” Novoa spoke about ribosomal RNA modifications. They study ribosomal RNA modifications. There are more than 12 modifications in rRNA. The new generation of algorithms allows the detection of more […]
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Revolutionizing Infectious Disease with EIT and Oxford Nanopore

Emma Stanton from the Ellison Institute of Technology (EIT) in the UK presented at London Calling 2025 on “EIT Pathogena and Oxford Nanopore Technologies revolutionising infectious disease.” Stanton started as a medical doctor and spoke about interdisciplinary teams driving impacts for patient care. The Ellison Institute of Technology was envisioned by a co-founder of Oracle. […]
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Creating a Tonsil Atlas to Study Lymphocytic Leukaemia

Ivo Gut from the National Centre for Genomic Analysis in Spain presented at London Calling 2025 on “Going the extra mile to understand chronic lymphocytic leukaemia.” Gut explained that they wanted to focus on single-cell RNA-seq during leukemia and proposed studies to the European Research Commission. The team had preliminary data indicating two distinct clusters […]
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Improving Drinking Water Safety with Phage Research

Tonight I am in Seattle for the Allen Institute Open Science conference. I watched Rachel Samson P. from Cranfield University in the UK present on “Mapping coliphage diversity for next-generation drinking water security through the nanopore lens.” Samson gained expertise from graduate work to measure water quality and described using coliphage diversity as a proxy. […]
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Faster Turnaround in Infectious Disease Diagnosis with Metagenomics

Judith Breuer from the UCL Institute of Child Health in the UK presented at London Calling 2025 a session titled “How could we incorporate metagenomics into routine diagnostic microbiology?” Breuer defined metagenomics and explained how their work on rapid respiratory metagenomics. In the winter of 2024/2025, the group adapted their clinical metagenomics approaches for rapid […]
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London Calling 2025 ONT Application Updates

Sissel Juul, Vice President of Applications with Oxford Nanopore Technology and Sean McKenzie, Associate Director of Genomics Applications, provided the London Calling 2025 applications update. Juul explained that the applications team is global. Haplotype-resolved genetic variation detection and interpretation has been updated to use assembly approaches. However, assembly can be very challenging, especially with two […]
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Insights from KBase LISA: Base Calling in Sequencing

Tonight I started watching the recordings from the KBase LISA workshop. I watched the base calling session by Torben Nielsen from Lawrence Berkeley National Laboratory. Nielsen compared PacBio and Nanopore sequencing. PacBio is sequencing by synthesis with limited length. Base calling is performed by image processing. The native error rate for PacBio is about 15%, […]
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Conservation Through Genomics: Org.one’s Impact on Endangered Species

It was nice to have a break and good food for Thanksgiving! Tonight, I watched the ORG.one session from the Nanopore Community Meeting 2024 in Boston. The session’s title was “ORG.one—enabling endangered species to bounce back,” which I enjoyed. Dan Fordham, the Director of Strategic Management with ONT and EMEA, was the facilitator of the showcase. The Org.one […]
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