Tonight I started watching a longer session from Oxford Nanopore Technologies (ONT) summer programming. “The era of complete genomes, at any scale” was the title of a session Cora Vaher gave. They described how long-read sequencing with ONT has changed sequencing. Vaher stated that “the era of full genomes is coming” because there are many more discoveries to be made. Methylation and exploration of the dark genome will expand the applications available. SNPs, methylation, and population genetics for rare diseases are some examples. Vaher did explain that there are opportunities for new techniques and better throughput. For example, haplotype-resolved genetic and epigenetic variation will be available by simply enabling the feature. EPI2ME integration and collaborations with the 1000 Genomes Project will strengthen and improve these features. Nanopore will offer a “Nanopore-only Telomere-to-telomere (TST) bundle” that includes the ultralong sequencing kit, pore-C, and assembly and polishing tool access. This bundle is not yet available but will be a “register your interest” program.
