Month: September 2024

Genomics England and ONT

I continued watching a longer session from Oxford Nanopore Technologies (ONT) summer programming tonight. “The era of complete genomes, at any scale” was the title of a session Cora Vaher gave. They talked about how methylation can be detected without additional library preparation. Haplotype-specific methylation could be very useful in learning about genetic diseases. Vaher shared a […]
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Unlocking Genomic Frontiers: ONT’s Long-Read Sequencing Breakthroughs

Tonight I started watching a longer session from Oxford Nanopore Technologies (ONT) summer programming. “The era of complete genomes, at any scale” was the title of a session Cora Vaher gave. They described how long-read sequencing with ONT has changed sequencing. Vaher stated that “the era of full genomes is coming” because there are many […]
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Personalized Medicine for Breast Cancer in the Caribbean: CariGenetics Pilot Study

I wanted to revisit Carika Weldon’s London Calling 2024 session tonight. Weldon founded CariGenetics in Bermuda and has presented in other London Calling sessions. The title of this session was “Towards personalised medicine for breast cancer in the Caribbean: a pilot study.” I wanted to watch this one since I heard about it from the […]
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Next-Generation Sequencing for Tuberculosis Detection: Insights from Findx Scientist

Tonight, I watched a recording on the ONT YouTube channel. Swapna Uplekar, a Principal Scientist in Genomics and Sequencing at Findx presented the session, “Targeted next-generation sequencing for drug-resistant tuberculosis detection.”Uplekar works at Findx to use next-generation sequencing to develop diagnostics for diseases globally. Tuberculosis, Uplekar emphasized, remains the top killer, worsened by COVID-19. Drug-resistant cases often remain […]
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Enhancing PulseNet Surveillance with Long-read Sequencing

Heather Carleton from the Centers for Disease Control & Prevention (CDC) presented at London Calling 2024. The session was titled “Whole-genome sequencing in PulseNet foodborne molecular surveillance systems.” They began discussing the impact of foodborne illness in the United States and globally. Carleton noted that in some cases, hospitalization and death occur. This impact affects […]
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Feasibility of Rapid Respiratory Metagenomic Sequencing for ICU Patients

Gaia Nebbia from the Guy’s and St. Thomas’ NHS Foundation Trust in the UK presented at London Calling 2024. The session focused on respiratory metagenomics in clinical service. This study explored metagenomic sequencing for respiratory infection control and diagnostics. The team identified areas of improvement for the identification of viral sequences. The aim of the […]
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Nanopore Sequencing Applications: Past, Present, and Future Insights with Sissel Juul, VP of Applications

I reached the London Calling 2024 session for the “10 years of nanopore sequencing applications.” Sissel Juul, VP of Applications, spoke about what the technology has enabled. The applications team worked on inspiring the community, showcasing the technology, and driving applications. Now, Juul noted, the team works with the community. Since 2014, the technology has […]
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Public Health Showcase 2024: One Health Genomics and Nanopore Sequencing

Tonight, I watched the London Calling 2024 Public Health Showcase. Associate Director of Global Segment Marketing Aaron Pomerantz helped moderate the session. Lara Urban from Helmholtz AI in Germany was the first speaker. Urban described the connections between One Health Genomics and Nanopore sequencing. One Health Policy was addressed with air microbiome to assess the […]
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Direct Sequencing of Cytosine Modification States from Nanopore Long-Read Data

Dominic Halliwell from the University of Bath in the UK presented at London Calling 2024 on “Direct sequencing of cytosine modification states from nanopore long-read data.” They are a doctoral student and were partially funded by Oxford Nanopore Technologies (ONT). Halliwell spoke about 5mC, 5hmC, and later oxidation derivatives, emphasizing that genome methylation can be […]
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Advancing Cancer Detection with RNA Liquid Biopsies

Daniel Kim from the University of California, Santa Cruz, presented at London Calling 2024. The session was on “Advancing RNA liquid biopsy technology via nanopore sequencing.” The Kim lab is working on advancing cancer detection with liquid biopsies. RNA is secreted into the circulation in extracellular vesicles (EVs). Kim noted that EVs can protect RNA. […]
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