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EPI2ME Labs Metagenomics Workflows on the Cloud

Tonight I watched the London Calling 2023 product demo for “Analysing bacterial genomes – from species identification to AMR.” Stephen Rudd, Director of Bioinformatics Product at Oxford Nanopore Technologies (ONT), shared their work on EPI2ME labs products. They have been developing EPI2ME Labs workflows for several years. These are pre-installed workflows that can help solve […]
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Long-read Sequencing Can Identify RNA Isoforms and NMD Modulators

Evangelos Karousis is a Senior Researcher at the University of Bern, Switzerland and presented at the Nanopore Community Meeting 2021 on “Nanopore sequencing reveals endogenous NMD-targeted isoforms in human cells.” They began by describing what nonsense-mediated mRNA decay (NMD) can do how how they can be dangerous. Endogenous mRNAs can be targeted by NMD. In […]
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Bambu for Transcript Discovery

Andre Sim from the Genome Institute of Singapore (A*STAR) in Singapore spoke at the Nanopore Community Meeting 2021 about “Bambu – generating context-aware transcriptomes with Oxford Nanopore long-reads.” What a cool name! Sim explained that RNA sequencing technologies have evolved, but reference annotation for transcript analysis has remained relatively unchanged. Sim noted that fragments could […]
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Liftoff Annotation of Novel Genes from T2T Human Genome

Alaina Shumate from John Hopkins University presented at the Nanopore Community Meeting 2021 about “The annotation of novel genes in a complete human genome.” They began by describing how in 2003 scientists “finished” the Human genome Project but there still was missing sequence! In 2021, the Telomere-to-Telomere (T2T) Consortium actually completed the sequence of a […]
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Improving ‘Noisy’ Long-read RNA-Seq

Chenchen Zhu from Stanford University presented at London Calling 2022 on the “Systematic assessment of long-read RNA-Seq datasets and its application in transcriptome analysis.” They are interested in understanding RNA isoforms using long-read sequencing. Differences in start sites and isoforms can lead to disease. The experimental workflow that Zhu shared was using reverse transcription and […]
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The Delftia Project Presented at SENCER

I am impressed by the creativity and motivation that students generate when they latch onto something they are passionate about. The Delftia Citizen Science group of undergraduates launched an entirely online collaborative research, annotation, and public science initiative last fall. Lauren Ramilo and Daiza Norman helped coordinate a group that at times had a dozen […]
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