Softwares

Evaluating Hospital Infection Transmission with Nanopore Sequencing

Samuel Shelburne from the University of Texas MD Anderson Cancer Center presented at the Nanopore Community Meeting in Boston. The session’s title was “Use of Oxford Nanopore sequencing to evaluate potential transmission of hospital infections.” Shelburne began by discussing healthcare-associated infections (HAIs), which are among the top ten leading causes of death in the US! Infection Prevention […]
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Understanding RNA Modifications: Insights from Nanopore Sequencing

Logan Mulroney from the EMBL-EBI in the UK and Italy spoke at the Nanopore Community Meeting in Boston. The title of the session was “A survey of RNA modifications across the human transcriptome by direct RNA nanopore sequencing.” They spoke about RNA modification and their implications in diseases such as cancer. RNA modifications can have […]
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Post-Vaccination Insights: Antibody Sequencing Techniques

Scott Hickey, the Director of Commercial Applications at Oxford Nanopore Technologies, spoke at the ONT Biopharma Day in Boston. The session’s title was “Antibody discovery through post-vaccination single-cell transcriptomics and haplotype-resolved germline sequencing.” Hickey spoke about a de novo full-length antibody identification through sequencing. B cell activation and proliferation were described along with the diversity […]
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mRNA Vaccine Quality Control with Nanopore Sequencing

Helen Gunter from The BASE Facility of The University of Queensland in Australia presented at the ONT Biopharma Day. The session’s title was “Using nanopore sequencing for mRNA vaccine quality control: a journey from R&D to GMP.” They noted that since the COVID vaccines, there has been interest in synthetic mRNAs. Gunter spoke about the […]
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Advancements in Adventitious Agent Detection at ONT Biopharma Day

Serge Monpoeho from Regeneron Pharmaceuticals in the US presented at the ONT Biopharma Day in Boston. The title of the session was “Adventitious agent screening by long-read NGS.” They wanted to develop an Oxford Nanopore-driven adventitious agent detection system. They used the Ligation Sequencing Kit, heat extraction, and custom universal PCR primers. They ran for […]
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Navigating GMP Compliance for NGS Testing

Colette Cote from PathoQuest presented at the Biopharma Day at the Nanopore Community Meeting in Boston. The session’s title was “The art of GMP in the world of NGS: trials, tribulations and a whole lot of acronyms—a success story.” The speakers discussed GMP compliance and the history of next-generation sequencing. Cote explained that there is […]
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Advancements in AAV Genome Sequencing

Keith Connolly from Modalis Therapeutics spoke at the Biopharma Day in Boston. The title of the session was “Nanopore sequencing and functional screening of AAV genomes for optimal production and function.” Modalis is developing a platform for gene expression modulation. They have been packaging promoters, transgenes, poly(A) signals into AAV genomes. They have been using […]
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Innovative NESSI-Seq for Biomarker Discovery

Chad Pollard from Wasatch BioLabs spoke at the Biopharma Day at NCM Boston. The session’s title was “NESSI-Seq: novel cfDNA methylation assays for biomarker discovery and precision medicine.” Pollard described Wasatch BioLabs as a high-throughput nanopore sequencing lab. NESSI-Seq is a methylation analysis method. They developed a method to provide more methylation information than the […]
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Nanopore Sequencing in Cell Therapy Testing

Stacy L. Springs from the MIT Center for Biomedical Innovation presented at the NCM Biopharma Day in Boston on “Application of nanopore long-read sequencing to sterility testing for cell therapy products.” Springs spoke about the diversity of impurities in biological medicines. They spoke about the need for rapid sterility testing in cell therapy manufacturing. Springs […]
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Understanding CoNS-seq: A Breakthrough in Viral Safety

Charles A. Swofford from the MIT Center for Biomedical Innovation presented as part of the Biopharma Day in Boston. The title of the session was “A sensitive sample preparation pipeline for adventitious virus detection using nanopore sequencing.” They emphasized the importance of viral safety assurance for biologics. The two assays used are in vivo virus […]
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