methylation

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Updates from the CARD Applied Neurogenomics Team

Kimberley Billingsley from the National Institutes of Health in the USA spoke at London Calling 2025 on “Decoding the genomics of neurodegenerative diseases with large-scale, long-read sequencing.” This session was an update from the CARD Applied Neurogenomics group. Billingsley divided the session into three topics: long-read sequencing, methylation, and RNA sequencing. Billingsley emphasized that current […]
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Plant Genome Assembly Insights from ONT Workshop

Tonight I watched the Oxford Nanopore Technologies (ONT) PAG Industry Workshop session titled “A single-platform solution for plant de novo genome assembly.” Jeannie Mounger, a field applications scientist with ONT, was the presenter. They noted that for plant genome assembly there are several considerations. Plant genome size varies greatly: from Mb to Gb. Polyploidy varies […]
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Transforming Cancer Care with Nanopore Sequencing

I continued watching the “Nanopore Sequencing Ultra Rich Data for Cancer Research” webinar. It featured Sayonika Mohanta, the Market Segment Manager for Methylation with Oxford Nanopore Technologies (ONT). Mathilde Fiser from the Curie Institute presentation had the title “Transforming Cancer Care: Redefining Cancer Characterization and Predisposition Insights through Nanopore Sequencing.” Fiser explained that the identification of germline alterations […]
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Nanopore Sequencing: Transforming Cancer Research with Rich Data

The “Nanopore Sequencing Ultra Rich Data for Cancer Research” webinar featured Sayonika Mohanta, the Market Segment Manager for Methylation with Oxford Nanopore Technologies (ONT). Mohanta began by emphasizing that cancer research requires multimodal approaches. The example they presented was the use of WGS of cell-free or circulating tumor DNA combined with proteomics and methylation. They […]
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Advancements in Methylation Studies Using Nanopore Sequencing

Brynja Sigurpalsdottir, a Research Associate at deCODE genetics in Iceland, spoke as part of the Oxford Nanopore Technologies webinar. The title of the session was “Large-scale methylation studies using nanopore sequencing.” deCODE is a subsidiary of Amgen. Sigurpalsdottir spoke about 5-mCpG methylation calling for ONT data. Initially, Nanopolish was one of the first algorithms trained […]
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Transforming Cancer Care with Nanopore Sequencing

Mathilde Filser from the Curie Institute in France presented at the Nanopore Community Meeting in Boston. The title of the session was “Transforming cancer care: redefining cancer characterization and predisposition insights through nanopore sequencing.” They study tumors and spoke about using nanopore sequencing for variant analysis. They used nanopore and adaptive sampling. They prepared libraries […]
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Understanding Methylation’s Impact on Gene Expression

Brynja Sigurpalsodottir from deCODE Genetics in Iceland presented at the Nanopore Community Meeting in Boston. They explained how methylation can be detected with base-calling. The dataset they created is from 7,179 whole blood samples sequenced on R9.4 PromethION flow cells. The team compared sample-to-sample profiles and methylation approaches. The results were published and showed the […]
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Long-Read Sequencing: Key Insights from Rady Children’s Institute

Matthew Bainbridge from the Rady Children’s Institute for Genomic Medicine in the US spoke at the Nanopore Community Meeting in Boston. The session was titled “Long-read sequencing for detecting methylation dysregulation.” Bainbridge noted that they see almost 250,000 children a year and are the only children’s hospital in Riverside County. Most of the children they […]
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Innovative NESSI-Seq for Biomarker Discovery

Chad Pollard from Wasatch BioLabs spoke at the Biopharma Day at NCM Boston. The session’s title was “NESSI-Seq: novel cfDNA methylation assays for biomarker discovery and precision medicine.” Pollard described Wasatch BioLabs as a high-throughput nanopore sequencing lab. NESSI-Seq is a methylation analysis method. They developed a method to provide more methylation information than the […]
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Nanopore Sequencing Revolutionizes Cell Engineering

Daniel K. Fabian from Lonza in the UK presented at the Biopharma Day in Boston on “Precision cell engineering enabled through nanopore sequencing.” Lonza Biologics produces therapeutic molecules for clients using CHO cell-based manufacturing pipelines. The first step is the construction of the vector. The DNA is transfected into their cell line, and clones are […]
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