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Long-Read Sequencing: Key Insights from Rady Children’s Institute

Matthew Bainbridge from the Rady Children’s Institute for Genomic Medicine in the US spoke at the Nanopore Community Meeting in Boston. The session was titled “Long-read sequencing for detecting methylation dysregulation.” Bainbridge noted that they see almost 250,000 children a year and are the only children’s hospital in Riverside County. Most of the children they […]
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Post-Vaccination Insights: Antibody Sequencing Techniques

Scott Hickey, the Director of Commercial Applications at Oxford Nanopore Technologies, spoke at the ONT Biopharma Day in Boston. The session’s title was “Antibody discovery through post-vaccination single-cell transcriptomics and haplotype-resolved germline sequencing.” Hickey spoke about a de novo full-length antibody identification through sequencing. B cell activation and proliferation were described along with the diversity […]
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mRNA Vaccine Quality Control with Nanopore Sequencing

Helen Gunter from The BASE Facility of The University of Queensland in Australia presented at the ONT Biopharma Day. The session’s title was “Using nanopore sequencing for mRNA vaccine quality control: a journey from R&D to GMP.” They noted that since the COVID vaccines, there has been interest in synthetic mRNAs. Gunter spoke about the […]
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BioNTech’s mRNA Innovations: Fighting Diseases Effectively

Andreas Czech from BioNTech in Germany presented at the Biopharma Day in Boston on “The potential of therapeutic mRNA—and how to measure it.” They spoke about the vision of the BioNTech pharmaceutical company: to use the immune system’s power to fight cancer and other diseases. The company was founded in 2008 by three tumor immunologists. […]
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Advancements in AAV Genome Sequencing

Keith Connolly from Modalis Therapeutics spoke at the Biopharma Day in Boston. The title of the session was “Nanopore sequencing and functional screening of AAV genomes for optimal production and function.” Modalis is developing a platform for gene expression modulation. They have been packaging promoters, transgenes, poly(A) signals into AAV genomes. They have been using […]
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Innovative NESSI-Seq for Biomarker Discovery

Chad Pollard from Wasatch BioLabs spoke at the Biopharma Day at NCM Boston. The session’s title was “NESSI-Seq: novel cfDNA methylation assays for biomarker discovery and precision medicine.” Pollard described Wasatch BioLabs as a high-throughput nanopore sequencing lab. NESSI-Seq is a methylation analysis method. They developed a method to provide more methylation information than the […]
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Nanopore Sequencing in Cell Therapy Testing

Stacy L. Springs from the MIT Center for Biomedical Innovation presented at the NCM Biopharma Day in Boston on “Application of nanopore long-read sequencing to sterility testing for cell therapy products.” Springs spoke about the diversity of impurities in biological medicines. They spoke about the need for rapid sterility testing in cell therapy manufacturing. Springs […]
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Understanding CoNS-seq: A Breakthrough in Viral Safety

Charles A. Swofford from the MIT Center for Biomedical Innovation presented as part of the Biopharma Day in Boston. The title of the session was “A sensitive sample preparation pipeline for adventitious virus detection using nanopore sequencing.” They emphasized the importance of viral safety assurance for biologics. The two assays used are in vivo virus […]
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Nanopore Sequencing Revolutionizes Cell Engineering

Daniel K. Fabian from Lonza in the UK presented at the Biopharma Day in Boston on “Precision cell engineering enabled through nanopore sequencing.” Lonza Biologics produces therapeutic molecules for clients using CHO cell-based manufacturing pipelines. The first step is the construction of the vector. The DNA is transfected into their cell line, and clones are […]
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Understanding Structural Variants in Cancer Genomes

Michael Dean from the National Cancer Institute presented at the Nanopore Community Meeting in Boston on “Diverse structural variants cluster near breakage-fusion-bridge site in cancer genomes.” Dean spoke about oncogene amplification and the need for high-quality cancer genomes for SV analysis. They have developed a standard extraction method with size selection to obtain long reads. […]
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